{"id":75478,"date":"2022-12-06T21:58:21","date_gmt":"2022-12-06T21:58:21","guid":{"rendered":"https:\/\/one.sightlinemg.com\/armytimes\/uncategorized\/2022\/12\/06\/study-recruits-troops-to-see-how-sleep-deprivation-affects-the-brain\/"},"modified":"2026-08-08T14:20:39","modified_gmt":"2026-08-08T14:20:39","slug":"study-recruits-troops-to-see-how-sleep-deprivation-affects-the-brain","status":"publish","type":"post","link":"https:\/\/one.sightlinemg.com\/armytimes\/news\/your-army\/2022\/12\/06\/study-recruits-troops-to-see-how-sleep-deprivation-affects-the-brain\/","title":{"rendered":"Study recruits troops to see how sleep deprivation affects the brain"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A high-tech MRI may be able to detect precisely how <a href=\"https:\/\/www.militarytimes.com\/news\/your-military\/2019\/12\/12\/could-mild-brain-injuries-be-affecting-good-order-and-discipline-the-pentagon-wants-to-find-out\/\" target=\"_blank\">brain function<\/a> changes with lack of sleep. It\u2019s part of a troop study getting underway at the Uniformed Services University of Health Sciences in Bethesda, Maryland.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers will use General Electric\u2019s <a href=\"https:\/\/www.militarytimes.com\/news\/your-military\/2020\/10\/29\/this-study-is-recruiting-troops-for-mild-tbi-research\/\" target=\"_blank\">MRI system<\/a> Microstructure Anatomy Gradient for Neuroimaging with Ultrafast Scanning \u2015 or MAGNUS \u2015 to watch the brains of both healthy sleepers and the chronically sleep-deprived to see if the process the brain undergoes to clear out \u201cwaste\u201d every night is affected by insomnia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cSo, you now have, essentially, a hypothesis that if deep sleep is disrupted, and you\u2019re looking at short naps or going through incomplete stages of sleep \u2015 the question that some researchers asked was, does that pathway become less efficient?\u201d Luca Marinelli, GE\u2019s product leader, told Military Times on Thursday.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The idea is a follow-up from a previous USUHS-GE study using MAGNUS, a head-only system, to look at <a href=\"https:\/\/www.militarytimes.com\/news\/your-military\/2022\/08\/26\/pentagon-plan-aims-to-treat-prevent-tbis-for-the-long-haul\/\" target=\"_blank\">traumatic brain injury<\/a> markers in troops that can\u2019t be seen on a regular MRI.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThat was kind of like the pilot, you know, to prove out that the device works,\u201d Marinelli said. \u201cIt\u2019s powerful. It gives us insights that we were not able to get with conventional whole-body MRI systems.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The next step is to interrogate how the sleep disturbances, including those known to accompany TBI, affect the brain\u2019s ability to wash away waste products at the end of the day, the way the lymphatic system does for the body\u2019s other tissues.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The glymphatic pathway in the brain, according to a November release from GE, is basically the body\u2019s way of \u201cclearing your head\u201d during the night, and studies have shown it\u2019s particularly active during deep sleep.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/health.mil\/News\/Articles\/2022\/02\/09\/Tactical-Napping-and-Other-Tips-to-Sleep-Well-On-Deployment\" target=\"_blank\">Some studies have shown<\/a> that active duty troops are regularly getting fewer than six hours of sleep every night \u2014 even fewer than that when they\u2019re deployed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">GE is specifically interested in \u201cwatchstanders,\u201d Marinelli said, those who have regularly had to stay up all or most of the night as part of their duties, a common occurrence for sailors on ships underway or troops deployed to combat.<\/p>\n\n\n\t<aside class=\"smg-interstitial-link wp-block-smg-interstitial-link\">\n\t\t<a href=\"https:\/\/one.sightlinemg.com\/militarytimes\/news\/your-military\/2021\/11\/03\/centcom-didnt-properly-document-brain-injuries-after-2020-iraq-barrage\/\" class=\"smg-interstitial-link__inner\">\n\t\t\t\t\t\t\t<div class=\"smg-interstitial-link__media\">\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"225\" src=\"https:\/\/one.sightlinemg.com\/wp-content\/uploads\/2026\/08\/AP20013433567721.jpg.jpg?w=300\" class=\"smg-interstitial-link__image wp-post-image\" alt=\"\" \/>\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"smg-interstitial-link__content\">\n\t\t\t\t<span class=\"smg-interstitial-link__kicker\">Related<\/span>\n\t\t\t\t<h3 class=\"smg-interstitial-link__title\">CENTCOM didn\u2019t properly document brain injuries after 2020 Iraq barrage<\/h3>\n\t\t\t\t\t\t\t\t\t<p class=\"smg-interstitial-link__excerpt\">The Defense Department can&#039;t be sure that troops were properly treated or their conditions properly documented for the future.<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/a>\n\t<\/aside>\n\t\n\n\n<p class=\"wp-block-paragraph\">Troops and veterans being treated for sleep disturbances are the main recruiting pool, along with some subjects with normal sleep patterns for comparison.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study, funded by a Defense Department grant, is scheduled to take three years with 75 subjects total. After signing on for the study, Marinelli said, subjects will spend two weeks tracking their sleep, so researchers know whether to consider them for the test group or the control group.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There will then be an acclimation period in which subjects get comfortable while in the machine, followed by one solid sleep session with the MAGNUS, about three hours.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Then they\u2019ll have to see what the data says. If, as they hypothesize, the glymphatic pathway is disrupted by prolonged sleep deprivation, that\u2019s an interesting data point, but there\u2019s no treatment for it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cSo, this is going to be an opportunity to prove it out in a research domain \u2014 if that becomes something that you\u2019re able to say, \u2018Yep, it works,\u201d Marinelli said. \u201cThe hypothesis confirms there is this link that tells me that I can show, for certain people, there is this lack of glymphatic circulation during specific stages of sleep.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Further study can then be done to see whether restoring sleep through existing treatments \u2014 whether medication or other therapy \u2014 can get the glymphatic process back to normal.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIf I can tell you that your glymphatic system is not doing as well as it could be \u2026 and you respond well to sleep hygiene, then I\u2019m going to prescribe to you get eight hours of sleep a night,\u201d he said. \u201cBut if I need to give you a drug that improves your glymphatic system, I don\u2019t have that drug today.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Diagnostics tend to arrive long before therapeutic tools, he added, but learning about the biological processes around illnesses is often the first step toward developing treatments targeting those misaligned processes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers want to know how sleep deprivation affects brain 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